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Ku70 is known to be a repair protein as well as an inhibitor of apoptosis through its association with Bax . The results of the present study have also demonstrated that TSA induced cell death in CRC cells through increasing the acetylation of Ku70, a Bax-binding protein, which therefore promoted Bax release and translocation from the cytoplasm into mitochondria in order to stimulate apoptosis. Since Ku70 S155D-expressing MEFs display cell cycle arrest and activation of a DNA damage response, a phenotype observed in Aurora B inhibitor-treated MEFs, we hypothesized that Ku70 S155D Ku70 in TSA-induced apoptosis in the CRC cell lines HCT116 and HT29. Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis JIN MENG1,2*, FENG ZHANG1*, XU‑TAO ZHANG1, TAO ZHANG3, YU-HUA LI1, LEI FAN1, YANG SUN1, HE‑LONG ZHANG4 and QI‑BING MEI1 The current study focused on the role of Ku70, a DNA-dependent protein kinase (DNA-PK) complex protein, in pancreatic cancer cell resistance to gemcitabine.

1 Function; 2 Aging; 3 Clinical; 4 Nomenclature; 5 Interactions; 6 References Consequently, inhibition of the NHEJ pathway can modulate a radiation- or chemo-refractory disease presentation. The Ku70/80 heterodimer protein plays a Rabbit polyclonal Ku70 antibody. Validated in WB, IP, IHC, ICC/IF and tested in Human. Cited in 6 publication(s). Independently reviewed in 4 review(s). 5 Mar 2019 Gomez, JA, Gama, V, Yoshida, T, Sun, W, Hayes, P, Leskov, K, Boothman D, Matsuyama S. Bax-inhibiting peptides derived from Ku70 and 9 Nov 2020 (a) Ku70-and Ku80-siRNA significantly inhibited the mRNA levels of Ku70 and Ku80, respectively, compared with the control. (b) Western blot 19 Sep 2018 It has been previously shown that modulation of Ku70 acetylation by histone deacetylases (HDAC) inhibitors induced sensitization of cancer 23 Jan 2020 We demonstrated that PIM1 phosphorylates KU70 and initiates DNA repair signaling in PAH-PASMCs and that PIM1 inhibitors represent a 13 Apr 2017 Ku70 S155D vWA domain is sufficient to inhibit Aurora B in an in vitro kinase assay.

2005-12-16 · Inhibition of Endogenous Ku70 Expression Blocks R. conorii Internalization of Mammalian Cells (A) siRNA against Ku70 is able to efficiently block Ku70 expression in transfected HeLa cells as determined by immunoblot analysis of cell lysates. Actin was used as a protein loading control. The present study is the first to show in pancreatic cancer (PC) the growth inhibition and apoptosis by novel MDM2 inhibitors (MI-319 & 219) through reactivation of p53 pathway.

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Product Name: Ku70 Mouse mAb Gene Name: xrcc6 Protein Name: Source: Mouse In this study, we show that in flow cytometry, immunoblots (IB) and in lung sections, FLIP levels can be regulated, in vivo and in vitro, through SIRT1 activity inhibition by CMH (4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide), a small molecule that, as we determined here by structural biology calculations, docked into its nonhistone substrate Ku70-binding site. Figure 2 Effects of COX-2 inhibitors on the Ku70 and Ku80 protein and mRNA levels in AGS cells.

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These results suggest that the ubiquitin–proteasome proteolytic pathway plays a role in decreasing Ku70 levels in apoptotic cells. Our results demonstrate a key role for Ku70. Specifically, inhibition of HDAC activity leads to increased acetylation of Ku70, which disrupts its binding to Bax. In turn, Bax is released from Ku70, translocates to mitochondria, and triggers the release of cytochrome c and caspase-dependent apoptosis.
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A, top left, an Figure 2: AR inhibition triggers PARP activation in human prostate cancer. ensHS ens DNA-binding protein inhibitor ID-3 (ID-like protein inhibitor HLH ENSP00000300145 ENSG00000166896 ensHS ens Ku70-binding protein 3. TRPM-2,Ku70-Binding Protein 1,CLI,Testosterone-Repressed Prostate Protein SP-40,CLU,Complement Cytolysis Inhibitor,Clusterin,NA1/NA2,APOJ,Apo-J Ku70-Binding Protein 1. Senast uppdaterad: 2014-12-09. Användningsfrekvens: 1.

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Document Grep for query "Resehandlingar." and grep phrase ""

2019-05-17 The DNA-PK inhibitor, NU7441, could significantly inhibit DNA-PK and Ku70 expression, simultaneously further aggravating BP-induced apoptosis and DNA damage under high-glucose conditions. CONCLUSION: These data indicate that hyperglycaemia may enhance BP-induced neurotoxicity and DNA damage by inhibiting the DNA repair protein Ku70. Surprisingly, specific inhibitors of the Ku70/80 heterodimer are currently not available. We here describe an in silico, pocket-based drug discovery methodology utilizing the crystal structure of the Ku70/80 heterodimer. We identified a novel putative small molecule binding pocket and selected several potential inhibitors by computational screening. 2016-07-01 KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DNA Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in T-Cell Acute Lymphoblastic Leukemia (T-ALL) [corrected] High-glucose treatment inhibited the expression of Ku70 and enhanced bupivacaine-induced neurotoxicity.